1174765-73-1

Basic information

• Product Name: 1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(2-fluoroethyl)urea
• CAS NO: 1174765-73-1
• Molecular Weight: 398.461
• Mol File: 1174765-73-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(2-fluoroethyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(2-fluoroethyl)urea(1174765-73-1)
• EPA Substance Registry System: 1-(4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(2-fluoroethyl)urea(1174765-73-1)

Safety Data

• Hazardous Substances Data: 1174765-73-1(Hazardous Substances Data)

Upstream product

• 406-34-8 2-fluoroethylamine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1174765-77-5 4-(4-(3,6-dihydro-2H-pyran-4-yl)thieno[3,2-d]pyrimidin-2-yl)aniline 

Relevant articles and documents

Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

The morpholine hinge-region binding group on a series of pyrazolopyrimidine and thienopyrimidine mammalian target of rapamycin (mTOR) inhibitors was replaced with 3,6-dihydro-2H-pyran (DHP), giving compounds of equivalent potency and selectivity versus PI3K. These results establish the DHP group as a hinge-region binding motif for the preparation of highly potent and selective mTOR inhibitors.