117527-53-4Relevant academic research and scientific papers
Effect of XlogP and Hansen Solubility Parameters on Small Molecule Modified Paclitaxel Anticancer Drug Conjugates Self-Assembled into Nanoparticles
Zhong, Ting,Hao, Yan-Li,Yao, Xin,Zhang, Shuang,Duan, Xiao-Chuan,Yin, Yi-Fan,Xu, Mei-Qi,Guo, Yang,Li, Zhan-Tao,Zheng, Xiu-Chai,Li, Hui,Zhang, Xuan
, p. 437 - 444 (2018)
Small molecule modified anticancer drug conjugates (SMMDCs) can self-assemble into nanoparticles (NPs) as therapeutic NP platforms for cancer treatment. Here we demonstrate that the XlogP and Hansen solubility parameters of paclitaxel (PTX) SMMDCs is essential for SMMDCs self-assembling into NPs. The amorphous state of PTX SMMDCs will also affect SMMDCs self-assembling into NPs. However, the antitumor activity of these PTX SMMDCs NPs decreased along with their XlogP values, indicating that a suitable XlogP value for designing the SMMDCs is important for self-assembling into NPs and for possessing antitumor activity. For higher level XlogP SMMDCs, a degradable linker should be considered in the design of SMMDCs to overcome the problem of lower antitumor activity. It is preferable that the hydrophilic groups in the SMMDCs should be present on the surface of self-assembling NPs.
Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity
Deutsch,Glinski,Hernandez,Haugwitz,Narayanan,Suffness,Zalkow
, p. 788 - 792 (2007/10/02)
Taxol has shown good in vivo antitumor activity in a number of test systems. The formulation of taxol for antitumor testing has been difficult. Esterification at either C-2' or C-7 resulted in loss of in vitro tubulin assembly activity but not cytotoxicit
