117546-56-2

Usage

Uses

Used in Pharmaceutical Industry:
3-AzetidinaMine, 1-(1-Methylethyl)-, hydrochloride (1:2) is utilized as a key intermediate in the synthesis of a range of pharmaceutical drugs. Its unique structure and reactivity make it a valuable component in the development of new medications, contributing to the advancement of healthcare and treatment options.
Used in Chemical Industry:
In the chemical industry, 3-AzetidinaMine, 1-(1-Methylethyl)-, hydrochloride (1:2) serves as an intermediate in organic synthesis. Its properties allow it to be integrated into various chemical processes, facilitating the creation of new compounds and materials with diverse applications across different sectors.

Upstream product

• 193269-78-2 3-aminoazetidine-1-carboxylic acid tert-butyl ester 
• 67-64-1 acetone 
• 1210273-37-2 tert-butyl 3-aminoazetidine-1-carboxylate hydrochloride 

Relevant academic research and scientific papers

Optimization of a kilogram-scale synthesis of a potent cycloartenol triterpenoid-derived γ-secretase modulator

This work describes the demonstration of a kilogram-scale synthesis of a γ-secretase modulator from a plant-sterol-derived starting material. Key to developing a synthetic route capable of delivering a kilogram of the target compound was the development of a four-reaction telescope process and a selective O-alkylation of a triol intermediate. These improvements enabled the successful delivery of kilogram-scale batches of API for preclinical development studies.

COMPOUNDS FOR USE IN TREATING NEURODEGENERATIVE DISORDERS, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO

The present invention provides methods for preparing compounds useful as modulators of amyloid-beta production. Such compounds are useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides intermediates useful in carrying out such synthetic methods. Compounds of this invention are further illustrated by the embodiments, sub-embodiments, and species disclosed herein.

COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS

The present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer’s disease.