117549-88-9Relevant academic research and scientific papers
Small Molecule Analogs of Phospholipid-Metal Ion Binding Sites: Synthesis and Molecular Modeling of Cyclohexane-1,2,4-triol Triphosphates
Amburgey, Judith C.,Shuey, Steven W.,Pedersen, Lee G.,Hiskey, Richard G.
, p. 172 - 197 (1994)
Four diastereomeric cyclohexane-1,2,4-triol triphosphates were synthesized to serve as small molecule analogs of putative phospholipid-metal ion binding sites. The parent cyclohexane-1,2,4-triols were prepared and phosphorylated. Deprotection of the tris(
Synthesis of (±) cyclohexane-1(R), 2(R), 4(R)-triol-triphosphate, a deoxygenated analog of myo-inositol-1,4,5-triphosphate
Schmitt,Spiess,Schlewer
, p. 2013 - 2016 (2007/10/02)
For the use in the studies of inositol-phosphates, (±) cyclohexane-1(R), 2(R), 4(R)-triol-triphosphate 2 was synthesized from anisole. The synthesis used 1,2-benzenedimethanol as a ketone and phosphate protective group which induced easy crystallization of the intermediates. Regeneration of the free ketone 9 under mild conditions followed by its selective reduction and phosphorylation by the phosphite method gave the expected compound 2.
