1175636-14-2

Basic information

• Product Name: 3,4-dimethoxy-2-nitrobenzonitrile
• Synonyms: 3,4-dimethoxy-2-nitrobenzonitrile
• CAS NO: 1175636-14-2
• Molecular Formula: C9H8N2O4
• Molecular Weight: 208.17082
• Mol File: 1175636-14-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-dimethoxy-2-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethoxy-2-nitrobenzonitrile(1175636-14-2)
• EPA Substance Registry System: 3,4-dimethoxy-2-nitrobenzonitrile(1175636-14-2)

Safety Data

• Hazardous Substances Data: 1175636-14-2(Hazardous Substances Data)

Upstream product

• 677335-32-9 4-hydroxy-3-methoxy-2-nitrobenzonitrile 
• 74-88-4 methyl iodide 
• 2450-26-2 2-nitrovanillin 
• 2698-69-3 4-formyl-2-methoxy-3-nitrophenyl acetate 
• 881-68-5 vanillin acetate 
• 121-33-5 vanillin 

Relevant articles and documents

CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS

The present invention provides unified synthesis of the CI -CI 9 building blocks of halichondrins and analogs theoreof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hydridized carbon. The provided efficient selective coupling reactions can allow easy access to the CI -CI 9 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.