117580-82-2

Basic information

• Product Name: (4R,5R)-4-(N,N-diethylamino)-5-((1'R,2'S,5'R)-menthyloxy)-butyrolactone
• Synonyms: (4R,5R)-4-(N,N-diethylamino)-5-((1'R,2'S,5'R)-menthyloxy)-butyrolactone
• CAS NO: 117580-82-2
• Molecular Weight: 311.465
• Mol File: 117580-82-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,5R)-4-(N,N-diethylamino)-5-((1'R,2'S,5'R)-menthyloxy)-butyrolactone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-4-(N,N-diethylamino)-5-((1'R,2'S,5'R)-menthyloxy)-butyrolactone(117580-82-2)
• EPA Substance Registry System: (4R,5R)-4-(N,N-diethylamino)-5-((1'R,2'S,5'R)-menthyloxy)-butyrolactone(117580-82-2)

Safety Data

• Hazardous Substances Data: 117580-82-2(Hazardous Substances Data)

Upstream product

• 112968-75-9 (5R)-(L-menthyloxy)-2(5H)-furanone 
• 109-89-7 diethylamine 

Downstream Products

• 2216-51-5 (-)-menthol 
• 117554-07-1 (R)-2-diethylamino-1,4-butanediol 

Relevant articles and documents

ASYMMETRIC 1,4-ADDITIONS TO 5-ALKOXY-2(5H)-FURANONES ENANTIOSELECTIVE SYNTHESIS AND ABSOLUTE CONFIGURATION DETERMINATION OF β-AMINO-γ-BUTYROLACTONES AND AMINO DIOLS

The synthesis of enantiomerically pure β-amino-γ-butyrolactones via asymmetric conjugate addition of various amines to 5-methyloxy-2(5H)-furanone is described.This route provides access to new multifunctional homochiral building blocks.The absolute configuration of the β-amino-γ-butyrolactones is established by X-ray analysis and 1H NMR correlation.The conjugate addition of amines to 2(5H)-furanone, 5-alkyl-2(5H)-furanones and 5-alkoxy-2(5H)-furanones was studied and an enhanced reactivity was observed in 2(5H)-furanones due to a γ-alkoxy-effect.The synthetic utility of the asymmetric amine addition is illustrated in an efficient route to various optically pure 2-amino-1,4-butanediols.