1176-82-5

Basic information

• Product Name: Fluocortolone Acetate
• Synonyms: Fluocortolone Acetate;(6α,11β,16α)-21-(Acetyloxy)-6-fluoro-11- hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione;21-Acetoxy-6α-fluoro-11β-hydroxy-16α-Methylpregna-1,4-diene-3,20-dione;21-Acetoxyfluocortolone
• CAS NO: 1176-82-5
• Molecular Formula: C₂₄H₃₁FO₅
• Molecular Weight: 418.4983432
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 1176-82-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: Fluocortolone Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Fluocortolone Acetate(1176-82-5)
• EPA Substance Registry System: Fluocortolone Acetate(1176-82-5)

Safety Data

• Hazardous Substances Data: 1176-82-5(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

Uses

Fluocortolone (F500500) derivative. Glucocorticoid.

Upstream product

• 917-64-6 methyl magnesium iodide 

Downstream Products

• 152-97-6 fluocortolone 

Relevant articles and documents

Preparation method for fluocortolone

The invention relates to a preparation method for fluocortolone; through a Grignard reaction of a compound represented by the formula I, fluocortolone represented by the formula II is generated. The preparation method for fluocortolone is simple in route and easy to operate, has the raw material easy to obtain, and greatly reduces production costs and industrialized conditions.

Trimethyl siloxane steroid intermediates

A procedure for converting steroids characterized by presence of an 11βOH group into potent corticoids having one or more substituents, such as 6αF, 16α, 17α-hydroxy or isopropylidene dioxy, 16α or 16β methyl, Δ1,4 ; by reacting the 11β-hydroxy steroid with trichloromethyl siloxane steroid, thereby rendering the normally sensitive 11 substituent inert to the series of reactions which thereafter incorporate one or more of the desired above listed substituents into the steroid molecule. The siloxy group is then hydrolyzed to regenerate the 11β-hydroxy substituent. Many of the trimethyl siloxy steroids are novel compounds. The siloxane may be selectively cleaved by reaction of the finely divided steroid with 40-60% aqueous HF.