1176087-65-2Relevant academic research and scientific papers
An Efficient Method for the Synthesis of N-uracil-4-oxo-thiazolidines without Catalyst
Mohamed, Asmaa H.,Shaker, Raafat M.
, p. 2099 - 2104 (2019)
We have developed highly efficient, one-pot three component reaction of 5-amino-uracil and aromatic aldehydes with thioglycolic acid for the synthesis of N-uracil-thiazolidinones in excellent yields. The same products were also prepared by the reaction of Schiff bases of 5-amino-uracil with thioglycolic acid. In addition, benzylation of thiazolidinone derivatives and Schiff bases by using benzyl chloride was investigated. The results obtained from elemental microanalysis and different spectral data are in agreement with the assigned structures.
5-aminouracil as a building block in heterocyclic synthesis: Part I. One-pot synthesis of pyrimido[5,4-b]quinolin-2,4,9-triones under microwave irradiation without catalyst
Shaker, Raafat M.,Abd Elrady, Mohamed
experimental part, p. 1431 - 1437 (2009/06/20)
A series of 6,7,8,10-tetrahydropyrimido[5,4-b]quinolin-2,4,9-(1H,3H,5H)- triones 6 were synthesized through one-pot condensation of 5-aminouracil, aldehydes and dimedone in DMF under microwave irradiation without catalyst. The products 6a, d were oxidized to the 7,8-dihydro-pyrimido-[5,4-b]quinolin-2,4,9- (1H/,3H,6H)-triones 11a, b. Treatment of 6a, d and/or 11a, b with ethyl iodide in the presence of anhydrous potassium carbonate gave the ethylated derivatives 12a, b and 13a, b, respectively. The structures of the products were confirmed by elemental analyses, IR, MS, 1H, and 13C NMR spectra.
