932-52-5

Basic information

• Product Name: 5-Aminouracil
• Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-amino-;2,4-Dihydroxy-5-aminopyrimidine;3h)-pyrimidinedione,5-amino-4(1h;5-Amino-2,4(1H,3H)-pyrimidinedione;5-amino-uraci;Uracil, 5-amino-;5-AMINO-2,4-PYRIMIDINEDIOL;5-AMINO-2,4-DIHYDROXYPYRIMIDINE
• CAS NO: 932-52-5
• Molecular Formula: C₄H₅N₃O₂
• Molecular Weight: 127.1
• EINECS: 213-252-3
• Product Categories: PYRIMIDINE;Miscellaneous;Nucleic acids
• Mol File: 932-52-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 235.85°C (rough estimate)
• Flash Point: 262.2°C
• Appearance: Beige to brown/Fine Powder
• Density: 1.4748 (rough estimate)
• Vapor Pressure: 5.09E-11mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.19±0.10(Predicted)
• Water Solubility: 0.5 g/L (20 ºC)
• BRN: 127250
• CAS DataBase Reference: 5-Aminouracil(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Aminouracil(932-52-5)
• EPA Substance Registry System: 5-Aminouracil(932-52-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• RTECS: YQ8740000
• F: 10-23
• TSCA: Yes
• Hazardous Substances Data: 932-52-5(Hazardous Substances Data)

Usage

Uses

5-Aminouracil is a useful research chemical.

Chemical Properties

beige to brown fine powder

Safety Profile

Human mutation data reported.When heated to decomposition it emits toxic vapors ofNOx.

InChI:InChI=1/C4H5N3O2/c5-2-1-6-4(9)7-3(2)8/h1H,5H2,(H2,6,7,8,9)

Upstream product

• 51-20-7 5-bromouracil 
• 7664-41-7 ammonia 
• 89323-18-2 (2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-urea 
• 611-08-5 5-nitrobarbituric acid 
• 7647-01-0 hydrogenchloride 
• 861566-19-0 5-bromo-6-hydroxy-5-nitro-dihydro-pyrimidine-2,4-dione 
• 7732-18-5 water 
• 23899-73-2 4,5-diamino-1,2-dihydropyrimidin-2-one 
• 51-20-7 2,4-dihydroxy-5-bromopyrimidine 
• 7164-43-4 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid 

Downstream Products

• 55476-37-4 5-[bis-(2-hydroxy-ethyl)-amino]-1H-pyrimidine-2,4-dione 
• 133030-28-1 N-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-benzamide 
• 99973-68-9 4-chloro-2-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylamino)-benzoic acid 
• 77296-62-9 5-(1-thioureido)uracil 
• 40769-79-7 N-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide 
• 6912-98-7 sulfanilic acid-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylamide) 
• 86764-00-3 4-acetamido-N-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzenesulfonamide 
• 2435-76-9 5-diazouracil 
• 127726-93-6 1-(2,4-dihydroxypyrimidin-5-yl)-3-p-toluenesulfonylurea 
• 127726-92-5 5-(4-chlorobenzoyl)aminopyrimidine-2,4-diol 
• 18592-32-0 5-benzyloxycarbonylaminopyrimidine-2,4-diol 
• 86763-94-2 N-(2,4-Dihydroxy-pyrimidin-5-yl)-4-nitro-benzenesulfonamide 
• 86764-05-8 C₁₆H₁₁N₅O₁₀S₂ 
• 2499-96-9 2,4-dioxo-6-methylpyrido<3,2-d>pyrimidine 

Relevant articles and documents

Discovery of a bacterial 5-methylcytosine deaminase

5-Methylcytosine is found in all domains of life, but the bacterial cytosine deaminase from Escherichia coli (CodA) will not accept 5-methylcytosine as a substrate. Since significant amounts of 5-methylcytosine are produced in both prokaryotes and eukaryotes, this compound must eventually be catabolized and the fragments recycled by enzymes that have yet to be identified. We therefore initiated a comprehensive phylogenetic screen for enzymes that may be capable of deaminating 5-methylcytosine to thymine. From a systematic analysis of sequence homologues of CodA from thousands of bacterial species, we identified putative cytosine deaminases where a "discriminating" residue in the active site, corresponding to Asp-314 in CodA from E. coli, was no longer conserved. Representative examples from Klebsiella pneumoniae (locus tag: Kpn00632), Rhodobacter sphaeroides (locus tag: Rsp0341), and Corynebacterium glutamicum (locus tag: NCgl0075) were demonstrated to efficiently deaminate 5-methylcytosine to thymine with values of kcat/Km of 1.4 × 105, 2.9 × 104, and 1.1 × 103 M-1 s-1, respectively. These three enzymes also catalyze the deamination of 5-fluorocytosine to 5-fluorouracil with values of kcat/Km of 1.2 × 105, 6.8 × 104, and 2.0 × 102 M-1 s-1, respectively. The three-dimensional structure of Kpn00632 was determined by X-ray diffraction methods with 5-methylcytosine (PDB id: 4R85), 5-fluorocytosine (PDB id: 4R88), and phosphonocytosine (PDB id: 4R7W) bound in the active site. When thymine auxotrophs of E. coli express these enzymes, they are capable of growth in media lacking thymine when supplemented with 5-methylcytosine. Expression of these enzymes in E. coli is toxic in the presence of 5-fluorocytosine, due to the efficient transformation to 5-fluorouracil.

PYRIDO[3,2-d]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE

Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Composition of matter having bioactive properties

Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.