1176087-96-9Relevant academic research and scientific papers
5-aminouracil as a building block in heterocyclic synthesis: Part I. One-pot synthesis of pyrimido[5,4-b]quinolin-2,4,9-triones under microwave irradiation without catalyst
Shaker, Raafat M.,Abd Elrady, Mohamed
experimental part, p. 1431 - 1437 (2009/06/20)
A series of 6,7,8,10-tetrahydropyrimido[5,4-b]quinolin-2,4,9-(1H,3H,5H)- triones 6 were synthesized through one-pot condensation of 5-aminouracil, aldehydes and dimedone in DMF under microwave irradiation without catalyst. The products 6a, d were oxidized to the 7,8-dihydro-pyrimido-[5,4-b]quinolin-2,4,9- (1H/,3H,6H)-triones 11a, b. Treatment of 6a, d and/or 11a, b with ethyl iodide in the presence of anhydrous potassium carbonate gave the ethylated derivatives 12a, b and 13a, b, respectively. The structures of the products were confirmed by elemental analyses, IR, MS, 1H, and 13C NMR spectra.
