1176161-39-9Relevant academic research and scientific papers
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Miyashiro, Julie,Woods, Keith W.,Park, Chang H.,Liu, Xuesong,Shi, Yan,Johnson, Eric F.,Bouska, Jennifer J.,Olson, Amanda M.,Luo, Yan,Fry, Elizabeth H.,Giranda, Vincent L.,Penning, Thomas D.
, p. 4050 - 4054 (2009)
Based on screening hit 1, a series of tricyclic quinoxalinones have been designed and evaluated for inhibition of PARP-1. Substitutions at the 7- and 8-positions of the quinoxalinone ring led to a number of compounds with good enzymatic and cellular poten
INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE
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Page/Page column 35, (2008/12/06)
Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
