Bioorganic and Medicinal Chemistry Letters p. 4050 - 4054 (2009)
Update date:2022-09-26
Topics:
Miyashiro, Julie
Woods, Keith W.
Park, Chang H.
Liu, Xuesong
Shi, Yan
Johnson, Eric F.
Bouska, Jennifer J.
Olson, Amanda M.
Luo, Yan
Fry, Elizabeth H.
Giranda, Vincent L.
Penning, Thomas D.
Based on screening hit 1, a series of tricyclic quinoxalinones have been designed and evaluated for inhibition of PARP-1. Substitutions at the 7- and 8-positions of the quinoxalinone ring led to a number of compounds with good enzymatic and cellular poten
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