1176224-18-2

Basic information

• Product Name: phenylmethyl (2S)-2-amino-5-[(3R)-3-(1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-{[(methyloxy)carbonyl]amino}butyl)-1-piperidinyl]-5-oxopentanoate
• CAS NO: 1176224-18-2
• Molecular Weight: 647.787
• Mol File: 1176224-18-2.mol

Chemical Properties

• CAS DataBase Reference: phenylmethyl (2S)-2-amino-5-[(3R)-3-(1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-{[(methyloxy)carbonyl]amino}butyl)-1-piperidinyl]-5-oxopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: phenylmethyl (2S)-2-amino-5-[(3R)-3-(1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-{[(methyloxy)carbonyl]amino}butyl)-1-piperidinyl]-5-oxopentanoate(1176224-18-2)
• EPA Substance Registry System: phenylmethyl (2S)-2-amino-5-[(3R)-3-(1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-{[(methyloxy)carbonyl]amino}butyl)-1-piperidinyl]-5-oxopentanoate(1176224-18-2)

Safety Data

• Hazardous Substances Data: 1176224-18-2(Hazardous Substances Data)

Upstream product

• 1070871-78-1 methyl {4-(3'-ethyl-6-fluoro-2-biphenylyl)-4-hydroxy-4-[(3R)-3-piperidinyl]butyl}carbamate 
• 30924-93-7 Boc-Glu-OBn 

Relevant articles and documents

Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition

Discovery of potent renin inhibitors which contain a simplified alkylamino Asp-binding group and exhibit improved selectivity for renin over Cyp3A4 is described. Structure-function results in this series are rationalized based on analysis of selected compounds bound to renin, and the contribution of each molecular feature leading to the reduced P450 inhibition is quantified.