117631-60-4Relevant academic research and scientific papers
Chiral non-racemic dihydroxysulfones via hydrolytic kinetic resolutions - Synthesis of oxacyclic ring systems using intramolecular acylation strategies
Jin, Chunyang,Ramirez, Raina D.,Gopalan, Aravamudan S.
, p. 4747 - 4750 (2007/10/03)
A number of chiral non-racemic 1,2-dihydroxysulfones have been prepared in good yields and high enantiomeric excesses by hydrolytic kinetic resolution of the corresponding epoxysulfones with Jacobsen's (S,S)-salen(Co)III(OAc) catalyst. The intramolecular cyclization reactions of the acyl and ethoxycarbonyl derivatives of these dihydroxysulfones have been exploited to access a variety of functionalized chiral non-racemic cyclic ethers and lactones in good yields.
(S)-β,ω-Dihydroxyalkyl Phenyl Sulfones. Synthesis by Bakers' Yeast Reduction and Use as Precursors of Optically Active Lactones
Sato, Toshio,Okumura, Yoshiyuki,Itai, Junichi,Fujisawa, Tamotsu
, p. 1537 - 1540 (2007/10/02)
The enantioselective reduction of ω-hydroxy-β-ketoalkyl phenyl sulfones with bakers' yeast gives (S)-ω,β-dihydroxyalkyl phenyl sulfones, which are convenient precursors for optically active lactones as shown in the synthesis of (R)-4-hexanolide and (R)-umbelactone.
