70941-74-1Relevant academic research and scientific papers
Simple synthesis of β-acetoxy thiocyanates from oxiranes
Lukowska-Chojnacka, Edyta,Plenkiewicz, Jan
, p. 1999 - 2006 (2011/06/24)
A convenient and simple method for the preparation of previously unknown β-acetoxy thiocyanates by regioselective ring opening of the corresponding oxiranes with thiocyanate anion followed by acetylation is described. The shorter reaction times, better yields of the products, and easy workup are the advantages of this methodology.
7-Oxanorbornane and norbornane mimics of a distorted β-D- mannopyranoside: Synthesis and evaluation as β-mannosidase inhibitors
Buser, Stephan,Vasella, Andrea
, p. 3151 - 3173 (2007/10/03)
The racemic 7-oxanorbornanyl and norbornanyl aminoalcohols 3, 4, 42, 45, and 46 were synthesized and tested as snail β-mannosidase inhibitors. The amino tetraol 3 was obtained from the known sulfonyl acrylate 9 and furan 10. Esterification provided 11 tha
Homochiral oxazolidin-2-ones and imidazolidin-2-ones by tandem nucleophilic addition-conjugate addition
Ciclosi, Marco,Fava, Cristiana,Galeazzi, Roberta,Orena, Mario,Gonzalez-Rosende, Maria Eugenia,Sepulveda-Arques, Jose
, p. 1937 - 1943 (2007/10/03)
Treatment of both primary alcohols 1a,b and secondary amines 1c,d, tethered to a Michael acceptor with (R)-phenylethyl isocyanate in the presence of DBU gave in good yield and high stereoselection diastereomeric mixtures of oxazolidin-2-ones 2a,b and 3a,b
Stereoselective synthesis of trans-4,5-disubstituted oxazolidin-2-ones by intramolecular conjugate addition of N-p-toluenesulfonyl carbamates
Ciclosi, Marco,Fava, Cristiana,Galeazzi, Roberta,Orena, Mario,Sepúlveda-Arques, José,González-Rosende, Maria Eugenia
, p. 1173 - 1183 (2007/10/03)
p-Toluenesulfonyl carbamates (2a-d) were prepared starting from allylic alcohols (3), in which the double bond is conjugated with an electron withdrawing group. In the presence of a catalytic amount of DBU, an intramolecular cyclisation occurred, leading
Chiral non-racemic dihydroxysulfones via hydrolytic kinetic resolutions - Synthesis of oxacyclic ring systems using intramolecular acylation strategies
Jin, Chunyang,Ramirez, Raina D.,Gopalan, Aravamudan S.
, p. 4747 - 4750 (2007/10/03)
A number of chiral non-racemic 1,2-dihydroxysulfones have been prepared in good yields and high enantiomeric excesses by hydrolytic kinetic resolution of the corresponding epoxysulfones with Jacobsen's (S,S)-salen(Co)III(OAc) catalyst. The intramolecular cyclization reactions of the acyl and ethoxycarbonyl derivatives of these dihydroxysulfones have been exploited to access a variety of functionalized chiral non-racemic cyclic ethers and lactones in good yields.
Palladium- and light-enhanced ring-opening of oxiranes by copper chloride
Muzart, Jacques,Riahi, Abdelkhalek
, p. 323 - 336 (2007/10/02)
The yields of chlorohydrins formed by cleavage of epoxides by CuCl2 is increased in the presence of small amounts of PdCl2(MeCN)2.The conversion drops dramatically on carrying out the reaction in the dark.The regiochemistry of the ring-opening is sensitive to the nature of the substituents.
Eliminative and Addition Reactions. Part 42. Structural Effects on Reactivity and Mechanism in Eliminative Fission of Three-membered Rings
Piras, Pier P.,Stirling, Charles J. M.
, p. 1265 - 1272 (2007/10/02)
Three aspects of eliminative fission reactions of the type (i) have been studied.First, the effects of stabilisation of the carbon leaving group, Z, by nitro and by sulphonyl groups have been compared.The results show that stabilisation by nitro produces
