117635-41-3

Upstream product

• 100-27-6 2-(4-nitrophenyl)ethanol 
• 100-39-0 benzyl bromide 
• 1462-37-9 bromoethyl-2-benzyl ether 
• 137297-51-9 2-(2-(benzyloxy)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1408168-73-9 potassium [2-(benzyloxy)ethyl]-trifluoroboranuide 
• 586-78-7 para-nitrophenyl bromide 

Relevant academic research and scientific papers

Suzuki-Miyaura cross-coupling of potassium alkoxyethyltrifluoroborates: Access to aryl/heteroarylethyloxy motifs

The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient installation of this unit on a broad range of aryl and heteroaryl bromides.

ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

A new high yield preparation of benzyl phenethyl ethers by phase transfer catalysis

A phase transfer method to prepare benzyl phenethyl ethers from electron-rich benzyl halides and 2-phenylethanols supporting electron- withdrawing groups is described. The yields are excellent, in contrast to the very low ones previously reported for the same kind of compounds prepared by other ways.