117688-52-5Relevant academic research and scientific papers
Synthesis of acylguanidine analogues: inhibitors of ADP-induced platelet aggregation
Thomas,Nishizawa,Zimmermann,Williams
, p. 228 - 236 (1989)
Routine screening of compounds for inhibition of ADP-induced platelet aggregation in vitro revealed that 1'-hexamethylenebis[3-cyclohexyl-3-[(cyclohexylimino)(4-morpholinyl)methyl] urea] was active and represented the first example of a bis(acylguanidine) with possible antithrombotic activity. In order to develop a structure-activity relationship for this class of compounds, we synthesized a number of new bis(acylguanidines). These were tested in vitro, and several analogues were also active. Ex vivo testing revealed that compounds 22, 41, 58, and 70-73 were orally active in rats or guinea pigs.
Rare-earth metal tris(trimethylsilylmethyl) anionic complexes bearing one 1-phenyl-2,3,4,5-tetrapropylcyclopentadienyl ligand: Synthesis, structural characterization, and application
Xu, Ling,Wang, Zitao,Zhang, Wen-Xiong,Xi, Zhenfeng
, p. 11941 - 11948,8 (2020/10/15)
Synthesis and structural characterization of half-sandwich rare-earth metal tris(trimethylsilylmethyl) anionic complexes bearing one 1-phenyl-2,3,4,5- tetrapropylcyclopentadienyl ligand are achieved. These soluble anionic compounds show good reactivity in
