1176891-06-7Relevant academic research and scientific papers
Aerobic Linear Allylic C-H Amination: Overcoming Benzoquinone Inhibition
Pattillo, Christopher C.,Strambeanu, Iulia I.,Calleja, Pilar,Vermeulen, Nicolaas A.,Mizuno, Tomokazu,White, M. Christina
supporting information, p. 1265 - 1272 (2016/02/18)
An efficient aerobic linear allylic C-H amination reaction is reported under palladium(II)/bis-sulfoxide/Br?nsted base catalysis. The reaction operates under preparative, operationally simple conditions (1 equiv of olefin, 1 atm O2 or air) with
A catalytic, Bronsted base strategy for intermolecular allylic C-H amination
Reed, Sean A.,Mazzotti, Anthony R.,White, M. Christina
supporting information; experimental part, p. 11701 - 11706 (2009/12/08)
A Bronsted base activation mode for oxidative, Pd(II)/sulfoxide- catalyzed, intermolecular C-H allylic amination is reported. N,N-diisopropylethylamine was found to promote amination of unactivated terminal olefins, forming the corresponding linear allylic amine products with high levels of stereo-, regio-, and chemoselectivity. The predictable and high selectivity of this C-H oxidation method enables latestage incorporation of nitrogen into advanced synthetic intermediates and natural products.
