117708-50-6Relevant academic research and scientific papers
Flexible stereo- and regioselective synthesis of myo-inositol phosphates (Part 2): Via nonsymmetrical conduritol B derivatives
Podeschwa, Michael A. L.,Plettenburg, Oliver,Altenbach, Hans-Josef
, p. 3116 - 3127 (2007/10/03)
A practical route is described for the preparation of myo-inositol phosphates. Optically pure compounds can be prepared, in both forms, from p-benzoquinone by enzymatic resolution of a diacetoxyconduritol key intermediate. Monosubstituted inositol derivat
Studies related to synthesis of glycophosphatidylinositol membrane-bound protein anchors. 6. Convergent assembly of subunits
Madsen, Robert,Udodong, Uko E.,Roberts, Carmichad,Mootoo, David R.,Konradsson, Peter,Fraser-Reid, Bert
, p. 1554 - 1565 (2007/10/02)
Glycophosphatidylinositol anchors of membrane-bound proteins are thought to comprise a common pentasaccharide core containing mannan, glucosamine, and inositol residues. A synthetic route to this core is described. In addition, the complete heptasaccharide moiety of the rat brain Thy-1 membrane anchor, the first mammalian membrane anchor to be characterized, has been synthesized. In the case of the Thy-1 anchor, the synthetic plan is based on three building blocks comprising glucosamine-inositol, galactosamine-mannose, and trimannan residues. Although glycosyl donors other than n-pentenyl glycosides (NPGs) have been used in preparing each of these building blocks, the final assembly of the heptasaccharide utilizes NPGs as the only glycosyl donors. The mildness of the conditions for these coupling reactions has allowed us to make provisions for subsequent installation of the three phosphodiester units.
The synthesis and resolution of (+/-)-1,4-di-O-benzyl-2,3-O-isopropylidene-myo-inositol
Desai, Trupti,Gigg, Jill,Gigg, Roy,Martin-Zamora, Eloisa,Schnetz, Nathalie
, p. 135 - 144 (2007/10/02)
An improved procedure for the preparation of 1,2-O-isopropylidene-myo-inositol is described.Racemic 1,4-di-O-benzyl-2,3-O-isopropylidene-myo-inositol was prepared by tin-mediated benzylation of 1,2-O-isopropylidene-myo-inositol and resolved readily by cry
The synthesis and resolution of (+/-)-1,5,6-tri-O-benzyl-myo-inositol
Desai, Trupti,Fernandez-Mayoralas, Alfonso,Gigg, Jill,Gigg, Roy,Payne, Sheila
, p. 105 - 123 (2007/10/02)
Racemic 1,5,6-O-benzyl-myo-inositol was prepared by five routes and converted into 1,5,6-tri-O-benzyl-2,3-O-isopropylidene-myo-inositol, the camphanates of which were readily separated by chromatography.The absolute configurations of the chiral derivative
