1177248-62-2Relevant academic research and scientific papers
A Copper-Catalyzed Synthesis of Functionalized Quinazolines from Isocyanides and Aniline Tri- and Dichloroacetonitrile Adducts through Intramolecular C-H Activation
Nematpour, Manijeh,Rezaee, Elham,Tabatabai, Sayyed Abbas,Jahani, Mehdi
, p. 1441 - 1444 (2017)
A novel class of substituted quinazolines were prepared in good yields by a one-pot three-component reaction of isocyanides with adducts of anilines and tri- or dichloroacetonitrile, followed by intramolecular C-H activation, catalyzed by copper(I) iodide with l -proline as a ligand in acetonitrile at room temperature.
Synthesis and in vitro antiplasmodial evaluation of 4-anilino-2-trichloromethylquinazolines
Verhaeghe, Pierre,Azas, Nadine,Hutter, Sebastien,Castera-Ducros, Caroline,Laget, Michele,Dumetre, Aurelien,Gasquet, Monique,Reboul, Jean-Pierre,Rault, Sylvain,Rathelot, Pascal,Vanelle, Patrice
experimental part, p. 4313 - 4322 (2009/10/10)
To identify a new safe antiplasmodial molecular scaffold, an original series of 2-trichloromethylquinazolines, functionalized in position 4 by an alkyl- or arylamino substituent, was synthesized from 4-chloro-2-trichloromethylquinazoline 1, via a cheap, f
