3137-63-1Relevant articles and documents
Looking for new antiplasmodial quinazolines: DMAP-catalyzed synthesis of 4-benzyloxy- and 4-aryloxy-2-trichloromethylquinazolines and their in vitro evaluation toward Plasmodium falciparum
Gellis, Armand,Primas, Nicolas,Hutter, Sébastien,Lanzada, Gilles,Remusat, Vincent,Verhaeghe, Pierre,Vanelle, Patrice,Azas, Nadine
, p. 34 - 44 (2016/05/24)
A DMAP catalyzed synthesis of new 4-benzyloxy- and 4-aryloxy-2-trichloromethylquinazolines was studied, in a view to react 4-chloroquinazolines with poorly nucleophilic alcohols such as benzylic alcohols, via a simple and cheap SNAr reaction ap
Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum
Hamann, Anton R.,De Kock, Carmen,Smith, Peter J.,Van Otterlo, Willem A.L.,Blackie, Margaret A.L.
, p. 231 - 236 (2013/09/23)
Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitro biological activity of four of the compounds on the Plasmodium falciparum chloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 μM as the lowest inhibitory concentration.
Access to original vinylic chlorides in the quinazoline series via a monoelectronic transfer reaction approach
Maillard-Boyer, Martine,Castera-Ducros, Caroline,Verhaeghe, Pierre,Sifredi, France,Rathelot, Pascal,Vanelle, Patrice
scheme or table, p. 2719 - 2729 (2010/07/03)
A series of new quinazoline derivatives bearing a vinylic chloride group on the 2-position was prepared by using a consecutive SRN1 / ERC1 radical strategy. Copyright
