1177408-07-9Relevant academic research and scientific papers
Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor
Reux, Bastien,Nevalainen, Tapio,Raitio, Katri H.,Koskinen, Ari M.P.
experimental part, p. 4441 - 4447 (2009/11/30)
A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPγS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.
