588-96-5Relevant articles and documents
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Michaelis
, p. 258 (1894)
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Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions
Yang, Yu-Ming,Yan, Wei,Hu, Han-Wei,Luo, Yimin,Tang, Zhen-Yu,Luo, Zhuangzhu
, p. 12344 - 12353 (2021/09/02)
A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.
Preparation method of p-bromophenylalkyl ether
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Paragraph 0044-0058, (2020/07/15)
The invention relates to a preparation method of p-bromophenylalkyl ether, wherein the preparation method comprises the steps: carrying out bromination reaction on phenylalkyl ether, hydrobromic acidand an oxidant in an organic solvent to prepare p-bromophenylalkyl ether. A chlorinated non-polar solvent is used as a reaction solvent, so that the para-position substitution selectivity of the bromination reaction is greatly improved, the yield of the bromination reaction is remarkably improved, p-bromophenylalkyl ether is prepared by replacing an etherification reaction route with the bromination reaction, toxic diethyl sulfate does not need to be used in the preparation process, and potential safety hazards are avoided; meanwhile, the dosage of the solvent is greatly reduced, the loading capacity of the raw materials of a reaction kettle is greatly improved, the production efficiency is greatly improved, and the production time is shortened; the post-treatment is simple, the reaction solvent can be recycled, and the comprehensive production cost is reduced; the method has the advantages of easily available raw materials, simple operation, low risk, high yield, high product purity,small pollution of the whole process, and suitableness for large-scale industrial production.