1177451-85-2Relevant academic research and scientific papers
Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery
McGuigan, Christopher,Serpi, Michaela,Bibbo, Rita,Roberts, Helen,Hughes, Clare,Caterson, Bruce,Gibert, Ana Torrent,Verson, Carlos Raúl Alaez
, p. 5807 - 5812 (2008)
We report the application of the phosphoramidate ProTide approach, developed by us for antiviral nucleosides, to sugar derivatives with potential chondroprotection against osteoarthritis. In particular, N-acetylglucosamine was converted to a series of 06
