117757-68-3

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dichloro-4-iodobenzoic acid is used as a key intermediate in the synthesis of substituted spiroxazolidinones, which are somatostatin subtype receptor 5 (SSTR5) antagonists. These antagonists have potential applications in the treatment of various disorders, including neuroendocrine tumors and other conditions where SSTR5 plays a significant role.

Upstream product

• 78473-00-4 4-amino-3,5-dichlorobenzonitrile 
• 651058-99-0 methyl 3,5-dichloro-4-iodobenzoate 

Downstream Products

• 51-36-5 3,5-dichlorobenzoic acid 
• 1350760-11-0 2,6-dichloro-4'-fluorobiphenyl-4-carboxylic acid 
• 1350758-55-2 4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate 
• 1350760-15-4 2,6-dichloro-4'-fluorobiphenyl-4-carboxaldehyde 

Relevant academic research and scientific papers

BIARYL COMPOUND, PREPARATION METHOD AND USE THEREFOR

The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

Pesticidal compounds

Bicyclooctane pesticides of the formula are prepared by cyclisation of In these formulae R may be various organic groups and is preferably n-butyl or n-propyl while R2 is a polysubstituted phenyl group.