117758-87-9

Upstream product

• 20074-79-7 diethyl (4-aminobenzyl)phosphonate 
• 407-25-0 trifluoroacetic anhydride 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 332120-20-4 diethyl-bromo-[4-(trifluoroacetylamino)phenyl]methyl-phosphonate 
• 188752-80-9 tetraethyl ((4-hydroxyphenyl)methylene)bis(phosphonate) 
• 188752-81-0 tetraethyl-4-aminophenylmethylene-1,1-bisphosphonate 
• 332120-21-5 tetraethyl-4-(trifluoroacetylamino)phenylmethylene-1,1-bisphosphonate 
• 925684-71-5 tetraethyl (4-bromoacetamidophenyl)methylenebisphosphonate 

Relevant academic research and scientific papers

Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections

The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and/or the treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis.

Preparation of tetraethyl-4-hydroxyphenylmethylene-1,1-bisphosphonate by hydroxy-de-diazoniation of the corresponding diazonium salt of tetraethyl-4-aminophenylmethylene-1,1-bisphosphonate

Bisphosphonates are widely used in diagnosis and therapy of different bone diseases. They are useful agents in osteotic vectorization of antitumor and antiinflammatory drugs because of their potential to accumulate in the inorganic bone matrix hydroxylapa

N-Glycosyl phosphonamidates: Potential transition-state analogue inhibitors of glycopeptidases

The synthesis of N-glycosyl phosphonamidates has been accomplished via the coupling of peracetylated glycosylamines with an appropriate phosphonochloridate in the presence of pyridine. The resulting glycosyl phosphonamidate esters are dealkylated with bro

Antibodies which catalyze hydrolysis of ester bonds

An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds to a reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site.