188752-81-0

Upstream product

• 332120-21-5 tetraethyl-4-(trifluoroacetylamino)phenylmethylene-1,1-bisphosphonate 
• 117758-87-9 diethyl-4-(trifluoroacetylamino)phenylmethyl-phosphonate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 
• 332120-20-4 diethyl-bromo-[4-(trifluoroacetylamino)phenyl]methyl-phosphonate 
• 20074-79-7 diethyl (4-aminobenzyl)phosphonate 

Downstream Products

• 925684-71-5 tetraethyl (4-bromoacetamidophenyl)methylenebisphosphonate 
• 389056-63-7 1-{4-[bis(diethoxyphosphoryl)methyl]phenyl}-1,4-dihydro-4-oxoquinoline-3-carboxylic ethyl ester 
• 188752-89-8 3-{4-[bis(diethoxyphosphoryl)methyl]phenylamino}-2-(fluorobenzyl)-acrylic ethyl ester 

Relevant academic research and scientific papers

Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections

The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and/or the treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis.

Preparation of tetraethyl-4-hydroxyphenylmethylene-1,1-bisphosphonate by hydroxy-de-diazoniation of the corresponding diazonium salt of tetraethyl-4-aminophenylmethylene-1,1-bisphosphonate

Bisphosphonates are widely used in diagnosis and therapy of different bone diseases. They are useful agents in osteotic vectorization of antitumor and antiinflammatory drugs because of their potential to accumulate in the inorganic bone matrix hydroxylapa