1177641-16-5Relevant academic research and scientific papers
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites
Geurink, Paul P.,Van Der Linden, Wouter A.,Mirabella, Anne C.,Gallastegui, Nerea,De Bruin, Gerjan,Blom, Annet E. M.,Voges, Mathias J.,Mock, Elliot D.,Florea, Bogdan I.,Van Der Marel, Gijs A.,Driessen, Christoph,Van Der Stelt, Mario,Groll, Michael,Overkleeft, Herman S.,Kisselev, Alexei F.
, p. 1262 - 1275 (2013/03/29)
Proteasomes degrade the majority of proteins in mammalian cells by a concerted action of three distinct pairs of active sites. The chymotrypsin-like sites are targets of antimyeloma agents bortezomib and carfilzomib. Inhibitors of the trypsin-like site se
