1177698-04-2

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 2972-72-7 2-(3-methoxybenzylidene)malononitrile 
• 591-31-1 3-methoxy-benzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 1184722-14-2 7-(3-methoxyphenyl)-5-oxo-2-((1S,2R,3R)-1,2,3,4-tetrahydroxybutyl)-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitrile 
• 1184722-20-0 1,5,7-triamino-6-benzoyl-4-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carbonitrile 
• 1184722-19-7 methyl (2E)-cyano[6,8-dicyano-7-(3-methoxyphenyl)-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridin-2(3H)-ylidene]acetate 
• 1184722-12-0 C₂₁H₁₅N₅O₂ 
• 1184722-18-6 2-(dicyanomethylene)-7-(3-methoxyphenyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitrile 
• 1184721-95-6 C₁₅H₉N₅O₂ 
• 1184722-16-4 2-cyanomethyl-7-(3-methoxyphenyl)-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitrile 
• 1184722-13-1 C₂₁H₁₄BrN₅O₂ 
• 1184722-15-3 1,5-diamino-4-(3-methoxyphenyl)-2,7-dioxo-1,2,7,8-tetrahydro-1,8-naphthyridine-3,6-dicarbonitrile 
• 1184722-17-5 [6,8-dicyano-7-(3-methoxyphenyl)-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyanamide 
• 1184721-99-0 C₂₁H₁₃N₅O₂ 
• 1184721-97-8 C₁₇H₁₃N₅O₂ 
• 1184722-00-6 C₂₁H₁₂ClN₅O₂ 
• 1184722-01-7 C₂₂H₁₅N₅O₂ 

Relevant academic research and scientific papers

An efficient and ecofriendly synthesis of highly functionalized pyridones: Via a one-pot three-component reaction

A simple and convenient protocol has been developed for the synthesis of N-amino-3-cyano-2-pyridone derivatives by a one-pot reaction of cyanoacetohydrazide, activated nitrile substrates (malononitrile, ethyl cyanoacetate, cyanoacetamide) and aromatic ald

A convenient synthesis of [1,2,4]triazolo[1,5-a]pyridines and 1,8-naphthyridine of analgesic and anti-inflammatory profiles

Starting from 1,6-diamino-3,5-dicyano-4-aryl-2-pyridones, substituted triazolo[1,5-a]pyridines and 1,8-naphthyridine derivatives have been synthesized. All the synthesized compounds were fully characterized by spectroscopic, physical data, and elemental analyses. Some of triazolo[1,5-a]pyridines were tested with respect to their analgesic and anti-inflammatory activities. All tested compounds exhibited analgesic activities comparable or superior to Valdecoxib. The anti-inflammatory activity was present in all the tested compounds as well and exceeded that of Hydrocortisone.