117782-95-3

Usage

Uses

Used in Pharmaceutical Industry:
11β-hydroxy-16α,17α-<(1-methylethylidene)bis(oxy)>-3-oxoandrosta-1,4-diene is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain associated with various conditions. Its steroidal structure allows it to effectively target and modulate the immune response, making it a valuable treatment option for inflammatory disorders.

Upstream product

• 638-94-8 desonide 

Relevant academic research and scientific papers

Photochemistry of desonide, a non-fluorinated steroidal anti-inflammatory drug

The photochemistry of anti-inflammatory drug desonide (De, 1) was studied in aerobic as well as in anaerobic condition with different irradiation wavelengths (254, 310 nm) in acetonitrile and 2-propanol. All photoproducts obtained were isolated and characterized on the basis of IR, 1H-, 13C-NMR spectroscopy and elemental analysis study. The products were: 11β,21-dihydroxy-16α,17α-(1-methylethylidenedioxy)-1,5- cyclopregn-3-ene-2,20-dione 2 (254 nm), 11β-hydroxy-16α,17α-(1- methylethylidenedioxy)androsta-1,4-diene-3-one 3 (310 nm/2-propanol), 17β-hydroperoxy-11β-hydroxy-16α,17α-(1- methylethylidenedioxy)androsta-1,4-diene-3-one 4 (310 nm/O2/2- propanol). Cyclohexadienone moiety in ring A and keto group at C17 were found to be deeply modified by UV light therefore, loss of biological activity both during storage and in vivo can not be ruled out.

Identification and analysis of a degradation product of the glucocorticoid desonide in ointment.

The major degradation product of desonide in a pharmaceutical ointment formulation has been shown to be identical with the C-17-carboxylic acid obtained on oxidative cleavage of the alpha-ketol group of desonide with alkaline hydrogen peroxide. The pKa value of this acid has been estimated from chromatographic data.