638-94-8 Usage
Chemical Properties
Off-White Solid
Originator
Tridesilon,Dome,US,1972
Uses
Different sources of media describe the Uses of 638-94-8 differently. You can refer to the following data:
1. antifungal
2. Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).
3. Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.
Definition
ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
Indications
Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
Manufacturing Process
Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4-
Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4-
pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric
acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction
mixture is diluted with water (50 ml) and extracted with chloroform (3x25
ml), the combined extracts then being washed with water (30 ml) and dried
over anhydrous sodium sulfate. The residue obtained by removal of solvent
crystallized from ethyl acetate-petroleum ether as small plates (25 mg),
melting point 257°-260°C.
Brand name
Desowen (Galderma); Tridesilon (Perrigo).
Therapeutic Function
Antiinflammatory
Check Digit Verification of cas no
The CAS Registry Mumber 638-94-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 638-94:
(5*6)+(4*3)+(3*8)+(2*9)+(1*4)=88
88 % 10 = 8
So 638-94-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
638-94-8Relevant articles and documents
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Bernstein et al.
, p. 4573 (1959)
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A synthesis method of budesonide (by machine translation)
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Paragraph 0030; 0032; 0038; 0046; 0054, (2018/07/30)
The invention discloses a budesonide synthetic method, under the protection of inert gas, under the catalysis of the 1st catalyst, sulfur dioxide will prednisone acetate eliminated reaction, then under the catalysis of the 2nd catalyst, through the oxidizing agent after the elimination of the products of the oxidation reaction, then under the catalysis of the 3rd catalyst, after oxidation through the acetone to products of the condensation process, the condensation product of the 4th under catalysis of the catalyst for selective reduction, finally 5th after reduction of the product of the hydrolysis catalyst under the catalysis of the reaction Desonide; the invention relates to a synthesis method of budesonide to prednisone acetate as raw materials through eliminating, oxidation, condensation, reduction, hydrolysis can be budesonide, synthesis process all the solvent in the process of all the recycled, and the reaction process in the absence of a heavy metal involved in the reaction, the technological process is mild, low energy consumption, is a green clean synthesis method. (by machine translation)
NOVEL PROCESS FOR PREPARATION OF GLUCOCORTICOID STEROIDS
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, (2016/08/23)
The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group; aryl or heteroaryl group; or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring; R3 and R4 are same or different and each independently represents H or halogen; R5 is -OH or –OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.
