117784-06-2Relevant academic research and scientific papers
Synthesis of benzimidazo[1,2-c]quinazolines as possible bronchodilators
Rao, A. Raghu Ram,Bahekar, Rajesh H.
, p. 434 - 439 (2007/10/03)
Synthesis of some 6-aryl-benzimidazo[1,2-c]quinazolines 4 have been critically investigated. The first method, based on the condensation of substituted-1,3-benzoxazin-4-(3H)-one 2 with o-phenylenediamine followed by cyclization of the resulting 2-aryl-3-(
BEHAVIOUR OF 2-SUBSTITUTED 6,8-DIBROMO-3,1-BENZOXAZIN-4-ONES TOWARDS o-PHENYLENEDIAMINE AND ANTHRANILIC ACID; A CASE OF UNUSUAL CLEAVAGE OF 6,8-DIBROMO-2-METHYL-3,1-BENZOXAZIN-4-ONE
Ismail, M. Fekry,El-Khamry, Abdel Momen A.,Hamid, Hoda A. Abdel,Emara, Samir A.
, p. 3757 - 3760 (2007/10/02)
6,8-Dibromo-2-methyl-3,1-benzoxazin-4-one (1) reacts with o-phenylenediamine to give a mixture of 3,5-dibromoanthranilic acid (2), 2-methylbenzimidazole (3) and 3-(o-aminophenyl)-6,8-dibromo-2-methylquinazolin-4-one (4).However, when the reaction was conducted in ethanol or in the absence of solvent at elevated temperature, a mixture of (2) and (3) was obtained.A similar cleavage of (1) took place when it was allowed to react with anthranilic acid yielding a mixture of (2) and N-acetylanthranilic acid (6).The reaction of o-phenylenediamine with 6,8-dibromo-2-phenyl-3,1-benzoxazin-4-one (7) proceeded normally to give 3-(o-aminophenyl)-6,8-dibromo-2-phenylquinazolin-4-one (8) or 2-benzoylamino-3,5-dibromo-N-(o-aminophenyl)benzamide (9), depending upon the reaction conditions.
