117786-94-4

Usage

Uses

Used in Pharmaceutical Industry:
O-(2-Carboxyethyl)polyethylene glycol 3,400 is used as a reactant for the preparation of multifunctional polymeric micelles for antiviral treatment. The carboxyethyl group allows for the attachment of antiviral agents, enhancing their solubility, stability, and targeted delivery to infected cells.
Used in Cancer Therapy:
O-(2-Carboxyethyl)polyethylene glycol 3,400 is used as a reactant for the preparation of NO-PEGylated epirubicin, a chemotherapy agent. The PEGylation of epirubicin with O-(2-CEG)-PEG 3,400 improves the drug's pharmacokinetics, reduces side effects, and enhances its therapeutic efficacy against cancer cells.
Used in Biomaterials and Surface Modification:
O-(2-Carboxyethyl)polyethylene glycol 3,400 is used as a reactant for the preparation of functionalized oligomers and copolymers with terpyridine-metal complexing segments. These functionalized polymers can be used to modify the surface properties of biomaterials, such as increasing the sensitivity of carboxyl-terminated dendrimer-coated bioactive interfaces for protein microarrays.
Used in Cardiovascular Research:
O-(2-Carboxyethyl)polyethylene glycol 3,400 is used in studies of therapeutic usefulness for receptor-targeted blockage of oxidized low-density lipoprotein uptake. The carboxyethyl group can be used to conjugate targeting ligands, enabling the development of targeted therapies for atherosclerosis and other cardiovascular diseases.

Upstream product

• 127457-63-0 3-[2-(2-benzyloxyethoxy)ethoxy]propanoic acid 
• 186020-66-6 3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester 

Relevant academic research and scientific papers

PHTHALOCYANINE DYE COMPOUNDS, CONJUGATES AND METHODS OF USE THEREOF

Disclosed herein are phthalocyanine dyes, and conjugates thereof, useful as fluorescent reporters for bioassays, for optical imaging and as therapeutic conjugates as the photosensitizing agents in light-based therapies including photoimmuno therapy (PIT). Certain phthalocyanine dyes disclosed herein are water soluble, and possess photophysical and photochemical profiles useful for use in imaging or therapy.

NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

Provided herein are cryptophycin conjugates and compositions containing them. Methods of making and using such compounds also are provided

Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery

A small library of novel 3-O-pegylated carboxylate prodrugs (4a-4b) and 3-O-pegylated carbamate prodrugs (9a-9b) of naltrexone were synthesized. The goal behind the design of these prodrugs was to investigate their potential for microneedle-enhanced transdermal delivery. All the synthesized 3-O-pegylated carboxylate prodrugs (4a-4b) and 3-O-pegylated carbamate prodrugs (9a-9b) of naltrexone were found to have adequate stability in a transdermal formulation and improved apparent solubility compared to naltrexone. Viscosity effects were postulated to be responsible for the observed non-linearity in the flux-concentration profile of these prodrugs.

3-Fucosyl-N-acetyl lactosamine derivatives, and their biological applications

The invention relates to substitution derivatives of trisaccharide 3-fucosyl-N-acetyl lactosamine and to the immunological applications of these derivatives and of the trisaccharide itself particularly as diagnostic reagent and in therapy.