117788-16-6

Basic information

• Product Name: 1-isopropyl-2,3-diphenyl-1H-indole
• Synonyms: 1-isopropyl-2,3-diphenyl-1H-indole
• CAS NO: 117788-16-6
• Molecular Weight: 311.426
• Mol File: 117788-16-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-isopropyl-2,3-diphenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-isopropyl-2,3-diphenyl-1H-indole(117788-16-6)
• EPA Substance Registry System: 1-isopropyl-2,3-diphenyl-1H-indole(117788-16-6)

Safety Data

• Hazardous Substances Data: 117788-16-6(Hazardous Substances Data)

Upstream product

• 75-31-0 isopropylamine 
• 501-65-5 diphenyl acetylene 
• 603-35-0 triphenylphosphine 
• 591-50-4 iodobenzene 
• 35292-56-9 1-(1-Methylethyl)-1-phenylhydrazine 
• 768-52-5 N-Isopropylaniline 
• 24642-83-9 N-isopropyl-N-phenylnitrous amide 
• 117785-90-7 N'-[1,2-Diphenyl-eth-(Z)-ylidene]-N-isopropyl-N-phenyl-hydrazine 

Relevant articles and documents

Assembly of Indole Cores through a Palladium-Catalyzed Metathesis of Ar-X σ-Bonds

We describe the development of a new method for construction of highly substituted indole scaffolds through the strategic utilizing of the metathesis of Ar-X σ-bonds based on the dynamic nature of palladium-based oxidative addition/reductive elimination. A suitable and simple catalytic system has provided an appropriate platform for a productive ligand exchange and consecutive carbopalladation/C-H activation/amination of phosphine ligands with alkynes and aromatic/aliphatic amines for construction of structurally diverse indoles.

Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.

Co(III)-Catalyzed, Internal and Terminal Alkyne-Compatible Synthesis of Indoles

A Co(III)-catalyzed, internal and terminal alkyne-compatible indole synthesis protocol is reported herein. The N-amino (hydrazine) group imparts distinct, diverse reactivity patterns for directed C-H functionalization/cyclization reactions. Notable synthetic features include regioselectivity for a meta-substituted arylhydrazine, regioselectivity for a chain-branched terminal alkyne, formal incorporation of an acetylenic unit through C2-desilylation on a C2-silylated indole derivative, formal inversion of regioselectivity through consecutive C3-derivatization and C2-desilylation processes, and formal bond migration for a linear-chain terminal alkyne.