35292-56-9

Upstream product

• 885669-11-4 acetic acid-(N'-isopropyl-N'-phenyl-hydrazide) 
• 75-30-9 2-iodo-propane 
• 100-63-0 phenylhydrazine 
• 75-26-3 isopropyl bromide 
• 114-83-0 1-acetyl-2-phenylhydrazine 
• 42116-43-8 tert-butyl 2-phenylhydrazine-1-carboxylate 
• 768-52-5 N-Isopropylaniline 
• 3314-35-0 3-Amino-1-phenyl-2-pyrazoline 
• 106087-11-0 3-Amino-1-isopropyl-1-phenyl-4,5-dihydro-1H-pyrazol-1-ium; iodide 
• 24642-83-9 N-isopropyl-N-phenylnitrous amide 

Downstream Products

• 25221-05-0 Benzophenon-N-isopropyl-N-phenylhydrazon 
• 99380-56-0 (E)-2-Ethyl-3-(N'-isopropyl-N'-phenyl-hydrazino)-but-2-enenitrile 
• 136119-34-1 (Z)-1-(N'-Isopropyl-N'-phenyl-hydrazino)-5-methyl-hex-1-en-3-one 
• 136119-34-1 (E)-1-(N'-Isopropyl-N'-phenyl-hydrazino)-5-methyl-hex-1-en-3-one 
• 1416897-72-7 (E)-methyl 3-(2-(isopropylamino)phenyl)acrylate 
• 117788-16-6 1-isopropyl-2,3-diphenyl-1H-indole 
• 76051-12-2 methyl 2-(isopropylphenylhydrazono)-4-phenyl-4-oxobutyrate 
• 77612-45-4 1-Isopropyl-1-phenyl-2-(3-sulfamoyl-4-chlorobenzoyl)-hydrazine 
• 885669-11-4 acetic acid-(N'-isopropyl-N'-phenyl-hydrazide) 

Relevant academic research and scientific papers

ACLY INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.

Ruthenium(II)-Catalyzed Traceless C?H Functionalization Using an N?N Bond as an Internal Oxidant

A previously elusive RuII-catalyzed N?N bond-based traceless C?H functionalization strategy is reported. An N-amino (i.e., hydrazine) group is used for the directed C?H functionalization with either an alkyne or an alkene, affording an indole derivative or olefination product. The synthesis features a broad substrate scope, superior atom and step economy, as well as mild reaction conditions.

MEDICINAL COMPOSITION

The present invention is composed of a pharmaceutical composition for the therapy of nephritis which comprises an amide derivative represented by the following formula [1] or pharmaceutically acceptable salt thereof, as an active ingredient: ???wherein R1 and R2 may be the same or different and each is hydrogen, alkyl which may be substituted, acyl, aryl which may be substituted, or an aromatic heterocyclic group which may be substituted; R3, R4, R5 and R6 may be the same or different and each is hydrogen, halogen, hydroxy, amino which may be substituted, alkyl which may be substituted, alkoxy or nitro and the like; and R7 represents cyclic amino which may be substituted or azabicycloalkylamino which may be substituted. The pharmaceutical composition of the invention is useful for the therapy of nephritis.

AMIDE DERIVATIVES AND DRUG COMPOSITIONS

The present invention is composed of an amide derivative represented by the following formula [1] or pharmaceutically acceptable salt thereof: ???wherein R1 and R2 may be the same or different and each is hydrogen, alkyl which may be substituted, acyl, aryl which may be substituted, or an aromatic heterocyclic group which may be substituted; R3, R4, R5, and R6 may be the same or different and each is hydrogen, halogen, hydroxy, amino which may be substituted, alkyl which may be substituted, alkoxy, or nitro and the like; and R7 represents cyclic amino which may be substituted or azabicycloalkylamino which may be substituted, and a pharmaceutical composition which comprises it as an active ingredient. The compound of the invention is useful as an inhibitor of TGF-β production or an antagonist of TGF-β.

AMIDRAZONES 9. CONVENIENT SYNTHESIS OF 1-ALKYL-1-PHENYLHYDRAZINES AND α,β-UNSATURATED AMIDRAZONES VIA BASE-PROMOTED REACTIONS OF 1,1-DISUBSTITUTED-3-AMNIO-4,5-DIHYDRO-1H-PYRAZOLIUM SALTS.

A simple, efficient procedure for the conversion of phenylhydrazine to 1-alkyl-1-phenylhydrazines via base-promoted hydrolysis of 1-alkyl-3-amino-4,5-dihydro-1-phenyl-1H-pyrazolium iodides (2) is described.N',N'-disubstituted hydrazones of trans-cinnamamide and acrylamide are obtained by Hofmann-type ring openings of 1,1-disubstituted-3-amino-4,5-dihydro-5-phenyl (or 5-unsubstituted) -1H-pyrazolium halides (5,7).