117811-87-7

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 

Downstream Products

• 117811-79-7 (2S,4R)-1-benzyloxycarbonyl-2-hydroxymethyl-4-methanesulfonyloxypyrrolidine 
• 756845-39-3 (-)-(3R,4S,7R)-2-benzyl-5-benzyloxycarbonyl-7-methanesulfonyloxy-3-phenyl-2,5-diazaspiro[3.4]octan-1-one 
• 756845-41-7 (+)-(3S,4R,7R)-2-benzyl-5-benzyloxycarbonyl-7-methanesulfonyloxy-3-phenyl-2,5-diazaspiro[3.4]octan-1-one 
• 756845-36-0 (4R)-N-benzyloxycarbonyl-4-methanesulfonyloxy-L-prolyl chloride 

Relevant academic research and scientific papers

Novel asymmetric approach to proline-derived spiro-β-lactams

We describe a novel asymmetric approach using Staudinger chemistry to proline-derived spiro-β-lactams. A chiral group at C-4 of the acid chloride of proline directs the stereoselectivity of Staudinger chemistry and later is sacrificed to obtain optically active 5.4-spiro-β-lactams. The scope, limitations, and mechanistic rationale for the observed results of Staudinger Chemistry of the acid chloride of 4-alkyl(aryl)sulfonyloxy-L-proline with imines are also discussed.

3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid compounds and antimicrobial activity thereof

This invention consists of 3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and their use as antimicrobial agents in the treatment of infectious diseases.