117811-87-7

Basic information

• Product Name: (2S,4R)-4-(methanesulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester
• Synonyms: (2S,4R)-4-(methanesulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester
• CAS NO: 117811-87-7
• Molecular Weight: 343.357
• Mol File: 117811-87-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-(methanesulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-(methanesulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester(117811-87-7)
• EPA Substance Registry System: (2S,4R)-4-(methanesulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester(117811-87-7)

Safety Data

• Hazardous Substances Data: 117811-87-7(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 

Downstream Products

• 756845-39-3 (-)-(3R,4S,7R)-2-benzyl-5-benzyloxycarbonyl-7-methanesulfonyloxy-3-phenyl-2,5-diazaspiro[3.4]octan-1-one 
• 756845-41-7 (+)-(3S,4R,7R)-2-benzyl-5-benzyloxycarbonyl-7-methanesulfonyloxy-3-phenyl-2,5-diazaspiro[3.4]octan-1-one 
• 117811-79-7 (2S,4R)-1-benzyloxycarbonyl-2-hydroxymethyl-4-methanesulfonyloxypyrrolidine 
• 756845-36-0 (4R)-N-benzyloxycarbonyl-4-methanesulfonyloxy-L-prolyl chloride 

Relevant articles and documents

Novel asymmetric approach to proline-derived spiro-β-lactams

We describe a novel asymmetric approach using Staudinger chemistry to proline-derived spiro-β-lactams. A chiral group at C-4 of the acid chloride of proline directs the stereoselectivity of Staudinger chemistry and later is sacrificed to obtain optically active 5.4-spiro-β-lactams. The scope, limitations, and mechanistic rationale for the observed results of Staudinger Chemistry of the acid chloride of 4-alkyl(aryl)sulfonyloxy-L-proline with imines are also discussed.