117828-35-0

Upstream product

• 117828-34-9 4,6-dimethoxy-2-(4-methoxyphenyl)-2-(2-cyanoethyl)-3-benzofuranone 
• 117828-32-7 4,6-dihydroxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 
• 117828-33-8 4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 

Downstream Products

• 117828-36-1 (3aS,8bS)-6,8-Dimethoxy-3a-(4-methoxy-phenyl)-8b-trimethylsilanyloxy-2,3,3a,8b-tetrahydro-benzo[b]cyclopenta[d]furan-1-one 

Relevant academic research and scientific papers

Optically Active Flavaglines-Inspired Molecules by a Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation

With the aid of a class of newly discovered Trost-type bisphosphine ligands bearing a chiral cycloalkane framework, the Pd-catalyzed decarboxylative dearomative asymmetric allylic alkylation (AAA) of benzofurans was achieved with high efficiency [0.2-1.0 mol% Pd2(dba)3/L], good generality, and high enantioselectivity (>30 examples, 82-99% yield and 90-96% ee). Moreover, a diversity-oriented synthesis (DOS) of previously unreachable flavaglines is disclosed. It features a reliable and scalable sequence of the freshly developed Tsuji-Trost-Stoltz AAA, a Wacker-Grubbs-Stoltz oxidation, an intra-benzoin condensation, and a conjugate addition, which allows the efficient construction of the challenging and compact cyclopenta[b]benzofuran scaffold with contiguous stereocenters. This strategy offers a new avenue for developing flavagline-based drugs.

A Synthetic Approach to Rocaglamide via Reductive Cyclization of δ-Keto Nitriles

The anticancer agent rocaglamide contains a novel bicyclooctanol structure.The approach to this molecule involved the preparation of a hydroxy ketone intermediate via a samarium-mediated cyclization.This ketone was then converted into an excellent