1178533-20-4

Basic information

• Product Name: 7-(difluoromethyl)-1,5-dimethyl-3-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione
• Synonyms: 7-(difluoromethyl)-1,5-dimethyl-3-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione
• CAS NO: 1178533-20-4
• Molecular Weight: 305.351
• Mol File: 1178533-20-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(difluoromethyl)-1,5-dimethyl-3-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(difluoromethyl)-1,5-dimethyl-3-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione(1178533-20-4)
• EPA Substance Registry System: 7-(difluoromethyl)-1,5-dimethyl-3-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione(1178533-20-4)

Safety Data

• Hazardous Substances Data: 1178533-20-4(Hazardous Substances Data)

Upstream product

• 41739-23-5 1,1-difluoro-1-phenyl-1,3-butanedione 
• 1316284-30-6 7-(chlorodifluoromethyl)-1,5-dimethyl-3-phenyl-1H-imidazo[4,5-b]pyridine-2(3H)-thione 
• 2375-76-0 1-chloro-1,1-difluoropentane-2,4-dione 

Relevant articles and documents

A general strategy for the synthesis of difluoromethyl-containing pyrazoles, pyridines and pyrimidines

Difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles are prepared by a two step method. The regioselective cyclizations of electron-excessive aminoheterocycles, hydrazines and amidines with CF 2Cl-substituted 1,3-dicarbonyl compounds provide the corresponding CF2Cl-substituted heterocycles. Subsequent radical reactions with trimethylstannane or allyltrimethylstannane gave difluoromethyl-containing heteroannulated pyridines, pyrimidines and pyrazoles, respectively.