1178560-59-2Relevant academic research and scientific papers
Total synthesis of (R)- and (S)-turmerone and (7S,9R)-bisacumol by an efficient chemoenzymatic approach
Kamal, Ahmed,Shaheer Malik,Azeeza, Shaik,Bajee, Shaik,Shaik, Ahmad Ali
experimental part, p. 1267 - 1271 (2009/10/17)
An enantioselective synthesis of (R)-, (S)-turmerone and (7S,9R)-bisacumol is described. The enantiomerically pure key intermediates, a substituted butanoate ester and acid are utilized in the synthesis of both enantiomers of turmerone. The lipase catalyzed resolution studies of the acetate of bisacumol have been exploited towards the total synthesis of the naturally occurring cytotoxic sesquiterpene, (7S,9R)-bisacumol with high diastereoselectivity (94% de).
