117872-45-4Relevant academic research and scientific papers
Synthetic Studies on Bicyclomycin and its Analogues. Part 1. Synthesis of Substituted 2-Oxa-8,10-diazabicyclodecanes
Dawson, Ian M.,Gregory, Julian A.,Herbert, Richard B.,Sammes, Peter G.
, p. 2585 - 2594 (2007/10/02)
Methods have been developed for formation of the eight-membered oxygen-containing ring system (2) present in the antibiotic bicyclomycin.The procedure starts with N,N'-disubstituted piperazine-2,5-diones or the corresponding mono imino ethers.A new method is based on the oxidation of the mono imino ethers using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as oxidant: the bis imino ethers gave pyrazines under these conditions, whilst the parent piperazinedione proved to be unreactive.
