117892-77-0

Usage

Uses

It helps in the synyhesis of of heterotactic polylactic acid from rac-lactide.

Upstream product

• 672-65-1 (1-chloroethyl)benzene 
• 7646-85-7 zinc(II) chloride 
• 7440-66-6 zinc 

Downstream Products

• 36617-88-6 (R)-3-phenyl-1-butene 
• 58717-85-4 (S)-3-phenyl-1-butene 
• 1433776-63-6 (R)-1-(4-methoxyphenyl)-4-phenylpentan-3-one 
• 1602605-41-3 1-(4-methoxyphenyl)-4-phenylpentan-3-one 
• 65248-44-4 methyl 4-oxo-5-phenylhexanoate 
• 77669-94-4 1-(3-methoxyphenyl)-2-phenylpropan-1-one 
• 1602605-65-1 4-(2-phenylpropanoyl)benzaldehyde 
• 1602605-66-2 1-(4-fluorophenyl)-5-phenylhexane-1,4-dione 
• 1602605-69-5 1-(4-chlorophenyl)-5-phenylhexane-1,4-dione 
• 1602605-49-1 (E)-1-(4-methoxyphenyl)-4-Phenylpent-1-en-3-one 
• 93433-64-8 2-phenyl-1-(o-tolyl)propan-1-one 
• 117269-69-9 1-cyclohexyl-2-phenylpropan-1-one 
• 2042-85-5 1,2-diphenylpropan-1-one 
• 117455-21-7 (4-(1-phenylethyl)phenyl)methanol 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS

The present invention relates to compounds of formula (I) for their use in the treatment and/or prevention of auto-immune or auto-immune related diseases, cancer, viral infections, and central nervous system diseases and disorders, by inhibiting human deh

Original 2-(3-Alkoxy-1 H -pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bearing analogues. As in our previous report, the structure-activity study of this series of human DHODH inhibitors was based on a phenotypic assay measuring measles virus replication. Among other inhibitors, this round of syntheses and biological evaluation iteration led to the highly active 5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-3-fluoropyridine. Inhibition of DHODH by this compound was confirmed in an array of in vitro assays, including enzymatic tests and cell-based assays for viral replication and cellular growth. This molecule was found to be more active than the known inhibitors of DHODH, brequinar and teriflunomide, thus opening perspectives for its use as a tool or for the design of an original series of immunosuppressive agent. Moreover, because other series of inhibitors of human DHODH have been found to also affect Plasmodium falciparum DHODH, all the compounds were assayed for their effect on P. falciparum growth. However, the modest in vitro inhibition solely observed for two compounds did not correlate with their inhibition of P. falciparum DHODH.

Pd-catalyzed Fukuyama cross-coupling of secondary organozinc reagents for the direct synthesis of unsymmetrical ketones

The coupling of acyl electrophiles with organometallic reagents represents a convergent route toward complex and versatile ketone products. Despite the mild conditions and high functional group tolerance, the cross-coupling of carboxylic acid derivatives,

Polyfunctional benzylic zinc chlorides by the direct insertion of magnesium into benzylic chlorides in the presence of LiCl and ZnCl2

Benzylic zinc chlorides bearing various functional groups are smoothly prepared by the direct insertion of magnesium into benzylic chlorides in the presence of LiCl and ZnCl2. The Royal Society of Chemistry.