117932-41-9Relevant academic research and scientific papers
Asymmetric synthesis of H1 receptor antagonist (R,R)-clemastine
Lee, Sun Young,Jung, Jung Wha,Kim, Tae-Hyun,Kim, Hee-Doo
, p. 2131 - 2136 (2015)
The first asymmetric synthesis of (R,R)-clemastine (1) has been accomplished by the coupling of (R)-tertiary alcohol 2 and (R)-chloroethylpyrrolidine 3 via O-alkylation. (R)-Tertiary alcohol 2 was synthesized by stereoselective alkylation of chiral α-benz
Electronic polarizability-based stereochemical model for Sharpless AD reactions
Han, Peng,Wang, Ruji,Wang, David Zhigang
, p. 8873 - 8878 (2011/12/02)
Softness really is the hard force! Reported here was the critical yet long-overlooked role of electronic polarizability (i.e., softness) effect in controlling absolute stereochemical courses of general asymmetric induction events. Thus, a sensitive dependence of the sense of chiral induction on an alkene substrate's substituent electronic polarizability character was uncovered from a range of structurally highly comparable Sharpless asymmetric dihydroxylation (AD) systems, from which a new polarizability-based stereochemical model of predictive power was suggested.
