1179808-75-3Relevant academic research and scientific papers
Thienopyrrole acetic acids as antagonists of the CRTH2 receptor
Bonafoux, Dominique,Abibi, Ayome,Bettencourt, Brian,Burchat, Andrew,Ericsson, Anna,Harris, Christopher M.,Kebede, Tegest,Morytko, Michael,McPherson, Michael,Wallace, Grier,Wu, Xiaoyun
, p. 1861 - 1864 (2011)
The bioisosteric replacement of the indole core of CRTH2 antagonists using thienopyrroles was investigated, resulting in potent antagonists with good selectivity over DP1. Early ADME/PK assessment of this chemotype demonstrated bioavailability in mice.
Thienopyrroles and pyrrolothiazoles as new therapeutic agents
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Page/Page column 20, (2009/09/05)
The present invention is directed to novel compounds of Formula (I) wherein the variables are defined as herein. The compounds of Formula (I) are useful as CRTH2 antagonists and as such would be useful in treating certain conditions and diseases, especial
