Bioorganic and Medicinal Chemistry Letters p. 1861 - 1864 (2011)
Update date:2022-08-02
Topics:
Bonafoux, Dominique
Abibi, Ayome
Bettencourt, Brian
Burchat, Andrew
Ericsson, Anna
Harris, Christopher M.
Kebede, Tegest
Morytko, Michael
McPherson, Michael
Wallace, Grier
Wu, Xiaoyun
The bioisosteric replacement of the indole core of CRTH2 antagonists using thienopyrroles was investigated, resulting in potent antagonists with good selectivity over DP1. Early ADME/PK assessment of this chemotype demonstrated bioavailability in mice.
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