1179810-92-4

Basic information

• Product Name: 1-hydroxy-1-(3-(propen-3-yl)oxyphenyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one
• CAS NO: 1179810-92-4
• Molecular Weight: 282.299
• Mol File: 1179810-92-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-hydroxy-1-(3-(propen-3-yl)oxyphenyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxy-1-(3-(propen-3-yl)oxyphenyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one(1179810-92-4)
• EPA Substance Registry System: 1-hydroxy-1-(3-(propen-3-yl)oxyphenyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one(1179810-92-4)

Safety Data

• Hazardous Substances Data: 1179810-92-4(Hazardous Substances Data)

Upstream product

• 4664-01-1 3,4-pyridinedicarboximide 
• 41388-50-5 1-(allyloxy)-3-bromobenzene 

Downstream Products

• 1179810-93-5 1-hydroxy-1-(3-hydroxyphenyl)-1,2-dihydropyrrolo[3,4-c]pyridine-3-one 

Relevant articles and documents

Development of isoniazid-NAD truncated adducts embedding a lipophilic fragment as potential bi-substrate InhA inhibitors and antimycobacterial agents

Isoniazid-NAD truncated adducts embedding a lipophilic fragment were designed, synthesized and evaluated as inhibitors of the enoyl-acyl carrier protein (ACP) reductase (InhA) of Mycobacterium tuberculosis and as antimycobacterial agents. These compounds, planned as bi-substrate inhibitors and inspired from the active metabolite of isoniazid, combine both the nicotinamide moiety of the cofactor NAD and a lipophilic hydrocarbon chain mimic of the InhA substrate. The lipophilic fragment was introduced using either Suzuki-Miyaura cross-coupling or a classical nucleophilic substitution reaction. Several compounds developed in this work were indeed able to inhibit the InhA activity and showed promising antimycobacterial activities. However a direct correlation between the expressed activity and the bi-substrate mode of action could not yet be unambiguously demonstrated.