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117983-39-8

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117983-39-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 117983-39-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,9,8 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 117983-39:
(8*1)+(7*1)+(6*7)+(5*9)+(4*8)+(3*3)+(2*3)+(1*9)=158
158 % 10 = 8
So 117983-39-8 is a valid CAS Registry Number.

117983-39-8Downstream Products

117983-39-8Relevant articles and documents

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication

Bedford,Harris III,Howd,Goff,Koolpe,Petesch,Koplovitz,Sultan,Musallam

, p. 504 - 516 (2007/10/02)

A series of structurally related monosubstituted 1-[(alkenyloxy)methyl]-, 1-[(alkynyloxy)methyl]-, and 1-[(aralkyloxy)methyl]-2-[(hydroxyimino)methyl]-3-methylimidazolium halides were prepared and evaluated. All new compounds were characterized with respect to (hydroxyimino)methyl acid dissocation constant, nucleophilicity, and octanol-buffer partition coefficient. The alkynyloxy-substituted compounds were also evaluated in vitro with respect to reversible inhibition of human erythrocyte (RBC) acetylcholinesterase (AChE) and kinetics of reactivation of human AChE inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP). In vivo evaluation in mice revealed that coadministration of alkynyloxy-substituted imidazolium compounds with atropine sulfate provided significant protection against a 2 x LD50 challenge of GD. For the alkynyloxy-substituted imidazolium drugs there is a direct relationship between in vitro and in vivo activity: the most potent in vivo compounds against GD proved to be potent in vitro reactivators against EPMP-inhibited human AChE. These results differ from the observations made on the sterically hindered imidazolium compounds (see previous article) and suggest that several antidotal mechanisms of protective action may be applicable for the imidazolium aldoxime family of therapeutics. The ability of the alkynyloxy substituents to provide life-saving protection against GD intoxication was not transferable to the pyridinium or triazolium heteroaromatic ring systems.

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