118000-69-4

Usage

Type of compound

Heterocyclic compound

Constituent elements

Carbon (C), Hydrogen (H), Bromine (Br), Nitrogen (N), Oxygen (O)

Structural features

Contains both imidazole and pyridine rings

Substituents

4-bromophenyl group, methoxy group

Potential pharmacological and biological activities

Studied for potential applications in medicinal chemistry as a scaffold for drug discovery

Importance of synthesis and characterization

Essential for understanding potential uses and properties in various fields.

Upstream product

• 10167-97-2 2-amino-5-methoxypyridine 
• 99-73-0 para-bromophenacyl bromide 
• 33243-33-3 2,4-dibromoacetophenone 

Downstream Products

• 1027045-51-7 2-(4 - tributylstannylphenyl)-6-methoxyimidazo[1,2-a]pyridine 
• 118000-71-8 4-(6-Methoxy-imidazo[1,2-a]pyridin-2-yl)-benzaldehyde 
• 118000-70-7 4-(6-Methoxy-imidazo[1,2-a]pyridin-2-yl)-benzonitrile 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS AND USES THEREOF

Described herein are compounds of formula (I), and pharmaceutically acceptable salts, solvates, hydrates, isotopically labeled derivatives and radiolabeled derivative thereof, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for detecting and imaging Tau aggregates in the brain for detection of Alzheimer's disease (AD) in a subject.

USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME

The invention provides a reagent which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid. The reagent for detecting amyloid deposited in a biological tissue comprises the compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or nitrogen, R1 is a group selected from the group consisting of a hydrogen, hydroxyl group, carboxyl group, sulfuric acid group, amino group, nitro group, cyano group, non-radioactive halogen substituent, alkyl substituent with 1 to 4 carbon atoms and alkoxy substituent, with 1 to 4 carbon atoms, and R2 is a radioactive halogen substituent, provided that at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4.

NOVEL COMPOUNDS WITH AFFINITY FOR AMYLOID

It is intended to provide a compound effective as an image diagnosis probe targeting amyloid and a diagnostic agent for Alzheimer's disease comprising the compound. Provided is a compound represented by the following formula or a salt thereof: wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen, R1 is a group selected from the group consisting of hydrogen, hydroxyl group, carboxyl group, sulfuric acid group, amino group, nitro group, cyano group, non-radioactive halogen substituents, alkyl substituents with 1-4 carbon atoms and alkoxy substituents with 1-4 carbon atoms, and R3 is a radioactive halogen substituent, provided that at least one of A1 A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4, as well as a diagnostic agent for Alzheimer's disease comprising the compound represented by the above formula or a salt thereof.