118001-75-5

Upstream product

• 25148-68-9 N-methylbenzene-1,2-diamine dihydrochloride 
• 7467-35-8 (1-methyl-1H-benzimidazol-2-yl)methanol 
• 459-57-4 4-fluorobenzaldehyde 
• 4760-35-4 2-chloromethyl-1-methyl-1H-benzimidazole 

Downstream Products

• 1413429-74-9 5-{4-[(1-methyl-1H-benzimidazol-2-yl)methoxy]benzylidene}-1,3-thiazolidine-2,4-dione 
• 1413429-75-0 diethyl {4-[(1-methyl-1H-benzimidazol-2-yl)methoxy]benzylidene}propanedioate 
• 1413429-76-1 diethyl {4-[(1-methyl-1H-benzimidazol2-yl)methoxy]benzyl}propanedioate 
• 1026876-08-3 2-{cyclohexyl-[4-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-methoxy}-isoindole-1,3-dione 
• 1026582-24-0 O-{cyclohexyl-[4-(1-methyl-1H-benzoimidazol-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine 

Relevant academic research and scientific papers

Design, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPAR? partial agonists

The design and synthesis of benzimidazolyl and indolyl linked α-alkoxy phenylpropanoic acid derivatives and the β-keto ester analogues in an effort to develop novel peroxisome proliferator activated receptors ligands expected to exhibit PPARα and PPAR? pa

Heterocyclyl linked anilines and benzaldehydes as precursors for biologically significant new chemical entities

Benzylidene and benzyl thiazolidinediones, oxazolidinediones, isoxazolidinediones and their acyclic analogs like alpha alkylthio/alkoxy phenylpropanoic acids, beta-keto esters and tyrosine-based compounds possess broad therapeutic potential in general and as Peroxisome Proliferator Activated Receptors (PPARs) agonists in particular in the management of hyperglycemia and hyperlipidaemia for the treatment of Type 2 Diabetes (T2D). We have synthesised and characterized some novel and suitably substituted heterocyclyl linked benzaldehydes and anilines, which can be easily and very readily derivatized to all the above mentioned classes to generate new chemical entities of broader biological significance. Synthesis of their benzylidene thiazolidinedione and diethyl malonate and also benzyl diethyl malonate and alpha-bromoesters derivatives is reported in some of the cases in the present work. Indian Academy of Sciences.

Chalcone derivatives and drugs containing the same

PCT No. PCT/JP97/01652 Sec. 371 Date Nov. 17, 1998 Sec. 102(e) Date Nov. 17, 1998 PCT Filed May 16, 1997 PCT Pub. No. WO97/44306 PCT Pub. Date Nov. 27, 1997This invention relates to chalcone derivatives represented by the following formula (1): wherein A represents a phenyl group, a quinolyl group or the like, W represents a vinylene group or the like, and R1 to R5 each independently represent a carboxyl, cyano, alkyloxycarbonyl or like group, or salts of the chalcone derivatives, and also to drugs containing them as effective ingredients. These compounds have excellent cys-LT receptor antagonism, and are useful as antiallergic agents or the like.