118024-66-1Relevant academic research and scientific papers
Copper-catalyzed rearrangement of oximes into primary amides
Sharma, Sumeet K.,Bishopp, Simon D.,Liana Allen,Lawrence, Ruth,Bamford, Mark J.,Lapkin, Alexei A.,Plucinski, Pawel,Watson, Robert J.,Williams, Jonathan M.J.
scheme or table, p. 4252 - 4255 (2011/08/22)
The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc) 2 (1-2 mol %) was found to be effective for this transformation at 80 °C. The reaction was successful with either conventional or microwave heating. CuO and CuO/ZnO on activated carbon provided a competent reuseable heterogeneous catalyst which could be used in a batch process or in flow. Copper salts are much cheaper than the precious metals previously used for this rearrangement, and the reaction conditions are milder than those reported.
Cost efficient synthesis of amides from oximes with indium or zinc catalysts
Allen, C. Liana,Burel, Céline,Williams, Jonathan M.J.
supporting information; experimental part, p. 2724 - 2726 (2010/07/06)
Simple indium and zinc salts have been successfully used as catalysts for the rearrangement of oximes into primary amides. The direct synthesis of nitriles or primary amides from aldehydes has also been demonstrated using these inexpensive catalysts.
N-acylbenzotriazoles: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides
Katritzky,He,Suzuki
, p. 8210 - 8213 (2007/10/03)
Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) α-hydroxyamides from α-hydroxy acids and of (ii) perfluoroalkylated amides.
