306990-96-5

Upstream product

• 5429-28-7 4-(diethylamino)benzoic acid 
• 37073-15-7 1-(methanesulfonyl)-1H-1,2,3-benzotriazole 
• 95-14-7 1,2,3-Benzotriazole 

Downstream Products

• 68289-19-0 1,2-bis(4-(diethylamino)phenyl)ethane-1,2-dione 
• 95-14-7 1,2,3-Benzotriazole 
• 118024-66-1 4-(N,N-diethylamino)benzamide 

Relevant academic research and scientific papers

C-acylation of 2-methylfuran and thiophene using N-acylbenzotriazoles

Reactions of 2-methylfuran and thiophene with readily available N-acylbenzotriazoles (RCOBt, where R = 4-tolyl, 4-methoxyphenyl, benzyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-pyridyl and 1-naphthyl) in the presence of TiCl4 or ZnBr2 produced 2-methyl-4-acylfurans 2a-e and 2-acylthiophenes 3a-f in average yields of 54 % and 75 %, respectively. Literature yields for the preparation of the same compounds are significantly lower.

Regiospecific C-acylation of pyrroles and indoles using N-acylbenzotriazoles

Reactions of pyrrole (2) or 1-methylpyrrole (4) with readily available N-acylbenzotriazoles 1a - g (RCOBt, where R = 4-tolyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-furyl, 2-pyridyl, 2-indolyl, or 2-pyrrolyl) in the presence of TiCl4 produced 2

N-acylbenzotriazoles: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides

Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) α-hydroxyamides from α-hydroxy acids and of (ii) perfluoroalkylated amides.